IL-33 Polyclonal Antibody
Printable Datasheet
View 1 Product Image
IL-33 Antibody for Western blot
>> See 3 other antibodies for IL33
Entrez Gene ID:
（Human） 90865
UniProt ID:
O95760
| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human （Hu） Murine （Ms） Rat （Rt） |
| Immunogen: | A 19 amino acid peptide from near the center of human IL-33. |
| Ordering Information | ||||
| Pierce IL-33 Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA5-20398 | 100 ug | Purchase » | ||
| Storage: | Stored at -20ºC, avoid repeated freeze thaw cycles |
| Form: | 100 ug of affinity chromatography purified antibody （1 mg/ml） in PBS containing 0.02% sodium azide. |
| Applications | Dilution * |
| Western Blot （WB） | 1 ug/ml |
| * Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls. | |
| Product Specific Information |
| PA5-20398 targets IL-33 in WB applications and shows reactivity with Human, Murine, and Rat samples. The PA5-20398 immunogen is a 19 amino acid peptide from near the center of human IL-33. |
| General Information |
| Interleukin-33 （IL-33） is a recently identified member of the IL-1 family of cytokines whose other members include IL-1-a/beta, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein （IL-1RAcP）. Receptor binding of IL-33 activates NF-kappa-B and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. |
上海力敏實(shí)業(yè)有限公司代理Pierce抗體蛋白產(chǎn)品，咨詢(xún)
上海力敏實(shí)業(yè)有限公司代理Pierce抗體蛋白產(chǎn)品，咨詢(xún)
